Tilz Gernot P, Wiltgen Marco, Demel Ulrike, Faschinger Christian, Schmidinger Hannes, Hermetter Albin
Clinical Immunology and Jean Dausset Laboratory, Medical University of Graz, Auenbruggerplatz 8, 8036 Graz, Austria.
Wien Med Wochenschr. 2007;157(5-6):122-9. doi: 10.1007/s10354-007-0383-0.
Molecular medicine leads us towards an understanding of some diseases at the molecular level. Examples are the analysis of immune complexes and receptor-antireceptor compounds used in clinical medicine. Structural changes of some serum proteins occur in inflammation, neoplasia and autoimmunity. The detection and analysis of such structural modifications may offer a new field for the diagnosis, prognosis and therapy of some diseases. Modern medicine requires new technologies with high sensitivity, specificity and applicability. For the first time in Austria we have combined fluorescence correlation spectroscope (FCS), surface enhanced laser desorption ionisation--time of flight (SELDI-TOF) and the molecular modelling and visualization system according to the computer enhanced programs. Experimental and computational methods are combined in such a way that clinical data can be interpreted by theoretical methods at a molecular level or vice versa, the computational output delivers input for new investigations. One method brings us single results. In view of the spectrum of parameters relevant to clinical entities, multiplexing is a new way of development. Since the technologies are new, the scientifically interested reader should be informed about the matters arising.
分子医学引领我们在分子水平上理解某些疾病。例如临床医学中对免疫复合物和受体 - 抗受体化合物的分析。一些血清蛋白的结构变化发生在炎症、肿瘤形成和自身免疫过程中。对这些结构修饰的检测和分析可能为某些疾病的诊断、预后和治疗提供一个新领域。现代医学需要具有高灵敏度、特异性和适用性的新技术。在奥地利，我们首次将荧光相关光谱仪（FCS）、表面增强激光解吸电离飞行时间质谱仪（SELDI - TOF）以及根据计算机增强程序的分子建模和可视化系统结合起来。实验方法和计算方法以这样一种方式结合，即临床数据可以在分子水平上通过理论方法进行解释，反之亦然，计算结果为新的研究提供输入。一种方法只能带给我们单一的结果。鉴于与临床实体相关的参数范围，多重分析是一种新的发展方式。由于这些技术是新的，应该让有科学兴趣的读者了解由此产生的问题。
