Hayward Catherine P M, Eikelboom John
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Semin Thromb Hemost. 2007 Apr;33(3):273-82. doi: 10.1055/s-2007-971814.
Platelet function tests are widely used for the diagnosis of platelet disorders. In recent years there has been increasing interest in the use of platelet function tests to monitor antiplatelet drug therapy. Quality assurance is important to optimize the performance of laboratory assays but it has not been widely applied to platelet function tests. This deficiency likely reflects the need to use freshly collected blood samples for platelet function tests, and the complex, time-consuming nature of some assays such as aggregation studies. Platelet function testing lacks guidelines, is poorly standardized between laboratories, and rarely is evaluated by internal and external quality assurance exercises. The sensitivity, specificity, and diagnostic utility of some newer, simplified assays of platelet function have been evaluated in a range of clinical settings but corresponding quality assurance data for many established as well as emerging platelet function assays are lacking. Quality assurance issues relevant to testing platelet function are reviewed in this article, with a focus on their application to established and to new and emerging tests.
血小板功能检测广泛应用于血小板疾病的诊断。近年来，人们对使用血小板功能检测来监测抗血小板药物治疗的兴趣日益浓厚。质量保证对于优化实验室检测性能很重要，但尚未广泛应用于血小板功能检测。这种不足可能反映出进行血小板功能检测需要使用新鲜采集的血液样本，以及某些检测（如聚集研究）复杂且耗时的性质。血小板功能检测缺乏指导原则，实验室之间标准化程度低，很少通过内部和外部质量保证活动进行评估。一些更新的、简化的血小板功能检测方法的敏感性、特异性和诊断效用已在一系列临床环境中进行了评估，但许多既定的以及新兴的血小板功能检测方法缺乏相应的质量保证数据。本文综述了与血小板功能检测相关的质量保证问题，重点关注其在既定检测方法以及新出现的检测方法中的应用。
