Buhl R, Nabavi A, Wolff S, Hugo H H, Alfke K, Jansen O, Mehdorn H M
Department of Neurosurgery, University of Schleswig Holstein, Campus Kiel, Kiel, Germany.
Neurol Res. 2007 Jan;29(1):43-6. doi: 10.1179/174313206X153824.
With magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS), we tried to get more pre-operative information in patients with suspicious meningioma concerning the histologic diagnosis especially regarding WHO Grades I and II meningiomas. Apart from the known spectra and metabolites such as choline, creatine and N-acetyl-aspartate (NAA), recent publications have shown that lactate is often found in necrotic tumor tissue. Within a 2 year period, 39 patients with an intracranial meningioma were studied with MRS. In 62.5% of histologic atypical meningiomas (WHO Grade II), a lactate peak could be demonstrated in the pre-operative MRS. Interestingly, also patients with multiple meningiomas show different spectra of their tumors.
我们利用磁共振成像（MRI）和磁共振波谱（MRS），试图在疑似脑膜瘤患者中获取更多术前信息，以辅助组织学诊断，特别是关于世界卫生组织（WHO）I级和II级脑膜瘤的诊断。除了已知的波谱和代谢物，如胆碱、肌酸和N-乙酰天门冬氨酸（NAA）外，最近的研究表明，乳酸经常出现在坏死的肿瘤组织中。在两年的时间里，我们对39例颅内脑膜瘤患者进行了MRS研究。在62.5%的组织学非典型脑膜瘤（WHO II级）患者中，术前MRS可显示乳酸峰。有趣的是，患有多发性脑膜瘤的患者其肿瘤波谱也各不相同。
