关于谷氨酰胺对皮层扩展性抑制作用的一则注释。
A note on the action of glutamine on cortical spreading depression.
作者信息
Maranhão-Filho P de A, Leão A A
机构信息
Neurology Service, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Brazil.
出版信息
Cephalalgia. 1991 Sep;11(4):201-4. doi: 10.1046/j.1468-2982.1991.1104201.x.
Application of a solution of 1-glutamine, 75 mM, to the pia-arachnoid surface of the dorsolateral neocortex of rabbits under dial-urethane anaesthesia was found to reversibly render the tissue insusceptible to spreading depression. It is suggested that this amide may play a part in the opposition normally offered by the tissue to undergo spreading depression. Some evidence is adduced which seems to support this suggestion.
在氨基甲酸乙酯麻醉下，将75 mM的L-谷氨酰胺溶液应用于兔背外侧新皮质的软脑膜-蛛网膜表面，发现可使该组织可逆地对扩散性抑制不敏感。有人认为，这种酰胺可能在组织通常对扩散性抑制的抵抗中起作用。提出了一些证据似乎支持这一观点。
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