莱奥在啮齿动物和人类皮层中的扩散性抑制。

Spreading depression of Leão in rodent and human cortex.

作者信息

McLachlan R S, Girvin J P

机构信息

Department of Clinical Neurological Sciences, University of Western Ontario, University Hospital, London, Canada.

出版信息

Brain Res. 1994 Dec 12;666(1):133-6. doi: 10.1016/0006-8993(94)90295-x.

DOI:10.1016/0006-8993(94)90295-x

PMID:7889364

Abstract

Spreading depression (SD) has been implicated in the pathophysiology of a number of neurological conditions. The same methodology was used to elicit SD in anesthetized rats and in non-anesthetized patients undergoing cortical resections for intractable epilepsy. A slowly spreading DC potential shift (mean -9 mV) occurred in the cortex of 10 of 15 rats in association with attenuation of the electrocorticogram but this could not be reproduced in any of the human cortices (n = 23) where the mean potential shift was -0.56 mV (P < 0.0001). SD is more difficult to elicit in human than rodent cortex and may not occur in man.

摘要

扩散性抑制（SD）已被认为与多种神经系统疾病的病理生理学有关。在麻醉大鼠和接受顽固性癫痫皮质切除术的未麻醉患者中，采用了相同的方法来诱发SD。15只大鼠中有10只的皮质出现了缓慢扩散的直流电位偏移（平均-9 mV），同时伴有皮质电图衰减，但在任何人类皮质（n = 23）中均无法重现，人类皮质的平均电位偏移为-0.56 mV（P < 0.0001）。在人类中诱发SD比在啮齿动物皮质中更困难，且在人类中可能不会发生。