神经生长因子对损伤的PC12细胞的影响。
Effect of nerve growth factor on lesioned PC12 cells.
作者信息
Pechán P, Cízková D, Murgácová M, Malatová Z
机构信息
Institute of Neurobiology, Slovak Academy of Sciences, Kosice, Czechoslovakia.
出版信息
Cell Biol Int Rep. 1991 Jun;15(6):527-35. doi: 10.1016/0309-1651(91)90121-x.
The protecting effect of nerve growth factor (NGF) from hydrogen peroxide was studied on PC12 cells conditioned at 1 mM hydrogen peroxide with NGF and without NGF in comparison with cells treated with neither hydrogen peroxide nor NGF. NGF treatment of PC12 cells increased significantly the activity of catalase representing induction of free radical detoxifying mechanisms. The protection effect of NGF was reflected also on enhanced activities of choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) in the cells.
研究了神经生长因子（NGF）对过氧化氢的保护作用，以1 mM过氧化氢处理PC12细胞，分别添加NGF和不添加NGF，并与未用过氧化氢和NGF处理的细胞进行比较。用NGF处理PC12细胞可显著提高过氧化氢酶的活性，这代表自由基解毒机制的诱导。NGF的保护作用还体现在细胞中胆碱乙酰转移酶（ChAT）和乙酰胆碱酯酶（AChE）活性的增强上。
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