Lucas C A, Czlonkowska A, Kreutzberg G W
Neurosci Lett. 1980 Jul;18(3):333-7. doi: 10.1016/0304-3940(80)90307-9.
In the PC12 clonal nerve cell line derived from a rat pheochromocytoma, the activity of acetylcholinesterase (AChE) is regulated by nerve growth factor (NGF). The specific activity of AChE was significantly increased 2 days after exposure of PC12 cells to NGF (8 X 10(-8) M), and reached its maximal increase of 94% after 3 days. Thereafter the specific activity of AChE did not significantly vary during the following 7 days. AChE cytochemistry showed the enzyme activity to be localized predominantly in cisternae of the rough endoplasmic reticulum, with a strongly enhanced activity after NGF treatment.
在源自大鼠嗜铬细胞瘤的PC12克隆神经细胞系中，乙酰胆碱酯酶（AChE）的活性受神经生长因子（NGF）调节。将PC12细胞暴露于NGF（8×10⁻⁸ M）后2天，AChE的比活性显著增加，3天后达到最大增幅94%。此后，在接下来的7天里，AChE的比活性没有显著变化。AChE细胞化学显示该酶活性主要定位于粗面内质网的池内，NGF处理后活性显著增强。
