Amoli M M, Martin J, Miranda-Filloy J A, Garcia-Porrua C, Ollier W E R, Gonzalez-Gay M A
The Endocrinology and Metabolism Research Centre, Tehran University of Medical Sciences, Tehran, Iran.
Clin Exp Rheumatol. 2007 Jan-Feb;25(1 Suppl 44):S6-9.
To assess whether polymorphism of the interleukin (IL)-6 gene at the position -174 was implicated in the incidence of Henoch-Schönlein pur-pura (HSP). A further objective was to determine if any relationship existed with severe systemic complications of HSP, in particular with severe renal and gastrointestinal involvement.
Unselected patients from Northwest Spain with primary cutaneous vasculitis classified as HSP according to proposed criteria were studied. All patients included in the present study were required to have had at least 2 year's follow-up. Patients and controls were genotyped for a single biallelic (G/C) nucleotide polymorphism in the promoter region at the position -174 of the IL-6 gene by a polymerase reaction chain-restriction fragment length polymorphism (PCR-RFLP) method.
Forty-six Caucasian HSP patients and 124 healthy matched controls were studied. No allele or genotype differences between the whole group of HSP and controls were observed. This was also the case when HSP patients were stratified by the presence of gastrointestinal complications, nephritis, and permanent renal involvement (renal sequelae).
The polymorphism in IL-6 gene promoter (-174 G/C) does not appear to be a genetic risk factor for HSP in Northwest Spain.
评估白细胞介素（IL）-6基因-174位点的多态性是否与过敏性紫癜（HSP）的发病有关。另一个目的是确定其是否与HSP的严重全身并发症存在关联，尤其是与严重的肾脏和胃肠道受累情况的关系。
对西班牙西北部根据既定标准被归类为HSP的原发性皮肤血管炎患者进行非选择性研究。本研究纳入的所有患者均需有至少2年的随访。通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法，对患者和对照者进行IL-6基因启动子区-174位点的单一位点双等位基因（G/C）核苷酸多态性基因分型。
研究了46例白种人HSP患者和124例健康匹配对照者。未观察到整个HSP组与对照组之间的等位基因或基因型差异。当根据胃肠道并发症、肾炎和永久性肾脏受累（肾脏后遗症）的存在对HSP患者进行分层时，情况也是如此。
在西班牙西北部，IL-6基因启动子（-174 G/C）的多态性似乎不是HSP的遗传危险因素。
