Ferrer M, Kaplan A P
Department of Allergy, Clinica Universitaria, Universidad de Navarra, Pamplona, Spain.
Allergol Immunopathol (Madr). 2007 Mar-Apr;35(2):57-61. doi: 10.1157/13101339.
Chronic urticaria can be defined as the occurrence of widespread daily or nearly daily wheals for at least 6 weeks, which may be accompanied by angioedema. It is a disease with a considerable impact on patients' quality of life. Furthermore, these patients may undergo extensive laboratory evaluations seeking a cause only to be frustrated when none is found. There is no curative treatment for this disorder and we do not understand the mechanisms that lead to the onset of disease. However, in recent years there have been significant advances in the understanding of some of the molecular mechanisms that cause cutaneous inflammation that is manifest as urticaria and angioedema. In this review we will summarize our recent contributions to this field and try to offer insights regarding future directions for research.
慢性荨麻疹可定义为每日或几乎每日出现广泛的风团，持续至少6周，可能伴有血管性水肿。它是一种对患者生活质量有相当大影响的疾病。此外，这些患者可能会接受广泛的实验室检查以寻找病因，但却往往一无所获，只能感到沮丧。这种疾病尚无治愈方法，我们也不了解导致其发病的机制。然而，近年来在理解一些导致表现为荨麻疹和血管性水肿的皮肤炎症的分子机制方面取得了重大进展。在本综述中，我们将总结我们近期在该领域的贡献，并尝试就未来的研究方向提供见解。
