慢性免疫性神经病中CD1基因的多态性
Polymorphisms of CD1 genes in chronic dysimmune neuropathies.
作者信息
De Angelis Maria Vittoria, Notturno Francesca, Caporale Christina M, Pace Marta, Uncini Antonino
机构信息
Department of Human Motor Sciences University "G. d'Annunzio", Chieti--Pescara, Italy.
出版信息
J Neuroimmunol. 2007 May;186(1-2):161-3. doi: 10.1016/j.jneuroim.2007.03.001. Epub 2007 Apr 10.
CD1 are MCH-like glycoproteins specialized in capturing and presenting glycolipid to T cells. Expression of CD1 molecules has been observed on endoneurial machrophages in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and vasculitis and polymorphisms of CID1A and CD1E genes have been associated with susceptibility to develop Guillain-Barré syndrome. In 46 patients with CIDP, in 13 patients with multifocal motor neuropathy and in 132 controls we genotyped exon 2 of CD1A and CD1E genes. We found no association between chronic dysimmune neuropathies, with or without anti-ganglioside antibodies, and polymorphisms of CD1A and CD1E genes.
CD1是一类类似于主要组织相容性复合体（MCH）的糖蛋白，专门负责捕获糖脂并将其呈递给T细胞。在慢性炎症性脱髓鞘性多发性神经病（CIDP）和血管炎患者的神经内膜巨噬细胞上已观察到CD1分子的表达，并且CD1A和CD1E基因的多态性与吉兰-巴雷综合征的易感性相关。我们对46例CIDP患者、13例多灶性运动神经病患者和132名对照者的CD1A和CD1E基因外显子2进行了基因分型。我们发现，无论有无抗神经节苷脂抗体，慢性免疫性神经病与CD1A和CD1E基因多态性之间均无关联。
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