Geleijns Karin, Laman Jon D, van Rijs Wouter, Tio-Gillen Anne P, Hintzen Rogier Q, van Doorn Pieter A, Jacobs Bart C
Department of Neurology, Erasmus MC, Dr. Molewaterplein 50, Rotterdam, 3015 GE, The Netherlands.
J Neuroimmunol. 2005 Apr;161(1-2):183-9. doi: 10.1016/j.jneuroim.2004.12.001.
Polymorphisms in genes involved in regulation of immune homeostasis may be a susceptibility factor in the induction of cross-reactive anti-ganglioside antibodies after infection in patients with Guillain-Barre syndrome (GBS). In this study we assessed whether polymorphisms in the promoter region of Fas and FasL and sFas and sFasL are related to GBS or its distinct clinical or serological subgroups. We show that the A(-670)G SNP in the promoter region of Fas and high levels of sFas are associated with the presence of anti-ganglioside antibodies, suggesting that Fas-FasL interaction is involved in the production of cross-reactive antibodies in GBS.
参与免疫稳态调节的基因多态性可能是吉兰 - 巴雷综合征（GBS）患者感染后诱导交叉反应性抗神经节苷脂抗体的一个易感因素。在本研究中，我们评估了Fas、FasL以及sFas、sFasL启动子区域的多态性是否与GBS或其不同的临床或血清学亚组相关。我们发现Fas启动子区域的A(-670)G单核苷酸多态性以及高水平的sFas与抗神经节苷脂抗体的存在相关，这表明Fas - FasL相互作用参与了GBS中交叉反应性抗体的产生。
