Department of Immunology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
Pathol Oncol Res. 2011 Sep;17(3):669-75. doi: 10.1007/s12253-011-9367-x. Epub 2011 Jan 22.
CD1 molecules might contribute to anti-tumor immune response by presentation of tumor-derived lipid and glycolipid antigens to T cells and NKT cells. Polymorphisms in CD1 genes have been suggested to modify ligand binding of CD1 molecules and thereby change the antigen presenting ability of these molecules. The aim of this study was to investigate the exon 2 polymorphisms of CD1a and CD1d in several high incident cancers in Iran. For this purpose, 201 female breast cancer patients and 207 healthy women, 64 lung cancer patients and 95 healthy individuals and 109 patients with colorectal cancer and 109 healthy controls were recruited to this study. Using PCR-SSP method, no significant correlation was found in genotype and allele frequencies of CD1a between all three studied groups and their control counterparts. Moreover, a dominant frequency of CD1d 01 (A) allele was observed in the majority of studied individuals. No significant association between the CD1 polymorphisms and prognostic factors in breast, lung and colorectal cancers was detected. Our results highlight the conserved nature of CD1 genes and may point to the immuoregulatory functions of CD1 molecules in cancer that can be exerted through fine tuning of NK, T and NKT cells.
CD1 分子可通过向 T 细胞和 NKT 细胞呈递肿瘤衍生的脂质和糖脂抗原来促进抗肿瘤免疫反应。CD1 基因的多态性被认为可以改变 CD1 分子的配体结合，从而改变这些分子的抗原呈递能力。本研究旨在调查伊朗几种高发癌症中 CD1a 和 CD1d 的外显子 2 多态性。为此，本研究招募了 201 名女性乳腺癌患者和 207 名健康女性、64 名肺癌患者和 95 名健康个体以及 109 名结直肠癌患者和 109 名健康对照者。使用 PCR-SSP 方法，在所有三组研究对象及其对照组中，CD1a 的基因型和等位基因频率均无显著相关性。此外，在大多数研究对象中观察到 CD1d01(A)等位基因的显性频率。在乳腺癌、肺癌和结直肠癌中，CD1 多态性与预后因素之间未发现显著关联。我们的研究结果强调了 CD1 基因的保守性，可能表明 CD1 分子在癌症中的免疫调节功能可以通过精细调节 NK、T 和 NKT 细胞来发挥作用。
