小鼠造血干细胞和祖细胞表达肾上腺素能受体。
Murine hematopoietic stem cells and progenitors express adrenergic receptors.
作者信息
Muthu Kuzhali, Iyer Sivaraman, He L-K, Szilagyi Andrea, Gamelli Richard L, Shankar Ravi, Jones Stephen B
机构信息
Loyola University Medical Center, Department of Surgery, Building 110, Room 4251, 2160S First Avenue, Maywood, IL 60153, USA.
出版信息
J Neuroimmunol. 2007 May;186(1-2):27-36. doi: 10.1016/j.jneuroim.2007.02.007. Epub 2007 Apr 10.
Abstract
Association between the nervous and immune system is well documented. Immune cells originate within the bone marrow that is innervated. Thermal injury induces adrenergic stimulation, augments monocytopoiesis and alters the beta-adrenergic receptor (AR) profile of bone marrow monocyte committed progenitors. This provides an impetus to study AR expression in hematopoietic progenitors along myeloid lineage. Using FACS analysis and confocal microscopy, we report the expression of alpha1-, alpha2- and beta(2)-AR in enriched populations of ER-MP209(+) and ER-MP12(+) myeloid progenitors, CD117(+) and CD34(+) multi-potential progenitors and more importantly pluripotent stem cells suggesting a plausible role for catecholamine in hematopoietic development.
摘要
神经与免疫系统之间的关联已有充分记录。免疫细胞起源于受神经支配的骨髓。热损伤会引发肾上腺素能刺激，增强单核细胞生成，并改变骨髓单核细胞定向祖细胞的β - 肾上腺素能受体（AR）谱。这为研究沿髓系谱系的造血祖细胞中AR的表达提供了动力。通过流式细胞术分析和共聚焦显微镜，我们报告了α1 -、α2 - 和β(2) - AR在富集的ER - MP209(+)和ER - MP12(+)髓系祖细胞、CD117(+)和CD34(+)多能祖细胞以及更重要的多能干细胞群体中的表达，提示儿茶酚胺在造血发育中可能发挥作用。
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