Krausz M M, Kablan M, Rabinovici R, Klin B, Sherman Y, Gross D
Department of Surgery B, Hadassah University Hospital, Jerusalem, Israel.
Circ Shock. 1991 Sep;35(1):9-13.
Hypertonic saline (HTS) infusion in "uncontrolled" hemorrhagic shock (UCHS) leads to increased bleeding from injured vessels, fall in mean arterial pressure (MAP), and early mortality. The effect of injured vessel size on blood loss in response to HTS treatment was studied in Neurolidal Ketalar anesthetized Hebrew University strain rats. The animals were randomly assorted into 4 groups: In group I (n = 8) UCHS was induced by resection of 8% of the terminal portion of the rats' tail and the animals were untreated. In group II (n = 8) UCHS was induced as in group I and the animals were treated with 5 ml/kg NaCl 7.5% (HTS). In group III (n = 9) UCHS was induced by 50% resection of the animal's tail, and the animals were untreated. In group IV (n = 12) UCHS was induced as in group III and the animals were treated with 5 ml/kg HTS Resection of 8% of the animal's tail was followed by bleeding of 2.6 +/- 0.3 ml and fall in MAP from 107 +/- 7 to 80 +/- 10 torr (P less than .005) within 5 min. Resection of 50% of the animal's tail was followed by bleeding of 4.3 +/- 0.4 ml (P less than .01) and fall in MAP to 41 +/- 6 torr (P less than .001) after 5 min. Infusion of HTS in group II was followed by further blood loss of 4.9 +/- 07 ml within 4 hr while in untreated group I, blood loss was only 3.4 +/- 0.4 ml (P less than .05), MAP remained unchanged, and there was no mortality.(ABSTRACT TRUNCATED AT 250 WORDS)
在“未控制的”失血性休克（UCHS）中输注高渗盐水（HTS）会导致受伤血管出血增加、平均动脉压（MAP）下降以及早期死亡。在氯胺酮麻醉的希伯来大学品系大鼠中研究了受伤血管大小对HTS治疗后失血的影响。动物被随机分为4组：第一组（n = 8），通过切除大鼠尾巴末端的8%诱导UCHS，且动物未接受治疗。第二组（n = 8），UCHS诱导方式同第一组，动物接受5 ml/kg 7.5%氯化钠（HTS）治疗。第三组（n = 9），通过切除动物尾巴的50%诱导UCHS，且动物未接受治疗。第四组（n = 12），UCHS诱导方式同第三组，动物接受5 ml/kg HTS治疗。切除动物尾巴的8%后，5分钟内出血量为2.6±0.3 ml，MAP从107±7降至80±10托（P＜0.005）。切除动物尾巴的50%后，5分钟内出血量为4.3±0.4 ml（P＜0.01），MAP降至41±6托（P＜0.001）。第二组输注HTS后，4小时内进一步失血4.9±0.7 ml，而未治疗的第一组失血量仅为3.4±0.4 ml（P＜0.05），MAP保持不变，且无死亡情况。（摘要截断于250字）
