毛榆甲醇提取物及其馏分的抗血管生成活性。
Anti-angiogenic activity of the methanol extract and its fractions of Ulmus davidiana var. japonica.
作者信息
Jung Hyun-Joo, Jeon Hye-Jin, Lim Eun-Ju, Ahn Eun-Kyoung, Song Yun Seon, Lee Sanghyun, Shin Kuk Hyun, Lim Chang-Jin, Park Eun-Hee
机构信息
College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Republic of Korea.
出版信息
J Ethnopharmacol. 2007 Jun 13;112(2):406-9. doi: 10.1016/j.jep.2007.03.006. Epub 2007 Mar 12.
This study aimed to elucidate anti-angiogenic activity of Ulmus davidiana var. japonica that has been widely used in folk medicine. The methanol extract (UDE) of Ulmus davidiana var. japonica concentration-dependently displayed a strong inhibition in the chick chorioallantoic membrane (CAM) angiogenesis. The n-butanol fraction of UDE and subsequent 30% MeOH subfraction were identified to be most responsible for the anti-angiogenic activity.
本研究旨在阐明广泛应用于民间医学的光叶榆的抗血管生成活性。光叶榆的甲醇提取物（UDE）对鸡胚绒毛尿囊膜（CAM）血管生成呈浓度依赖性地表现出强烈抑制作用。UDE的正丁醇部位及随后的30%甲醇亚部位被确定对其抗血管生成活性起主要作用。
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