College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk 712-749, Republic of Korea.
Phytother Res. 2013 Sep;27(9):1376-80. doi: 10.1002/ptr.4882. Epub 2012 Nov 12.
The stem and root barks of Ulmus davidiana var. japonica (Ulmaceae) have been used to treat inflammatory diseases including mastitis, rhinitis, sinusitis, and enteritis. In an ongoing study focused on the discovery of natural anti-inflammatory compounds from natural products, a methanol extract of the stem and root barks of U. davidiana var. japonica showed anti-inflammatory activities. Activity-guided fractionation of the methanol extract yielded a new trihydroxy fatty acid, 9,12,13-trihydroxyoctadeca-10(Z),15(Z)-dienoic acid (1), and a known compound, pinellic acid (2). These two trihydroxy fatty acids 1 and 2 inhibited prostaglandin D₂ production with IC₅₀ values of 25.8 and 40.8 μM, respectively. These results suggest that 9,12,13-trihydroxyoctadeca-10(Z),15(Z)-dienoic acid (1) and pinellic acid (2) are among the anti-inflammatory principles in this medicinal plant.
日本榆（榆科）的茎和根皮已被用于治疗炎症性疾病，包括乳腺炎、鼻炎、鼻窦炎和肠炎。在一项旨在从天然产物中发现天然抗炎化合物的持续研究中，日本榆的茎和根皮的甲醇提取物显示出抗炎活性。对甲醇提取物进行活性导向分离得到了一种新的三羟基脂肪酸，9,12,13-三羟基十八碳-10(Z)，15(Z)-二烯酸（1）和一种已知的化合物，胡椒酸（2）。这两种三羟基脂肪酸 1 和 2 的前列腺素 D₂产生抑制作用的 IC₅₀值分别为 25.8 和 40.8 μM。这些结果表明，9,12,13-三羟基十八碳-10(Z)，15(Z)-二烯酸（1）和胡椒酸（2）是该药用植物中的抗炎成分之一。
