Peter Shajan, Beglinger Christoph
Department of Gastroenterology, University Hospital, Basel, Switzerland.
Digestion. 2007;75(1):25-35. doi: 10.1159/000101564.
Gastric cancer has been recognized as an important cause of morbidity and mortality all over the world. Helicobacter pylori has been shown to have a causal relationship to gastric cancer. The knowledge into the mechanisms related to this has advanced considerably over the last few years thereby unarguably defining the role of this host-pathogen interaction. Epidemiological studies, research in animal models, molecular pathways involving host and bacterial factors, environmental factors and recent work on stem cells have contributed to understanding the origin and progress of this neoplasia. These form part of the myriad of interplaying factors resulting in the causal relationship. Nevertheless, current evidence is insufficient to accurately identify a definitive population where prevention or treatment strategies have to be targeted. Future trials will have to define the people at risk and shed more light in these areas.
胃癌已被公认为全球发病和死亡的重要原因。幽门螺杆菌已被证明与胃癌存在因果关系。在过去几年里，人们对与此相关的机制的认识有了很大进展，从而明确了这种宿主-病原体相互作用的作用。流行病学研究、动物模型研究、涉及宿主和细菌因素的分子途径、环境因素以及最近关于干细胞的研究，都有助于理解这种肿瘤的起源和发展。这些构成了导致因果关系的众多相互作用因素的一部分。然而，目前的证据不足以准确确定必须针对预防或治疗策略的特定人群。未来的试验将必须确定高危人群，并在这些领域提供更多信息。
