Young Robert C, Kiosses Dimitris, Heo Moonseong, Schulberg Herbert C, Murphy C, Klimstra Sibel, Deasis Jose M, Alexopoulos George S
Institute of Geriatric Psychiatry, Weill Medical College of Cornell University, New York, NY, USA.
Bipolar Disord. 2007 May;9(3):301-4. doi: 10.1111/j.1399-5618.2007.00393.x.
Clinicians have suggested that manic psychopathology in adulthood changes with advanced age. We used rating scale evaluations of manic psychopathology in adult patients with bipolar (BP) disorder to test whether older age is associated with scores on items related to excesses of behaviors: i.e., Sexual Interest, Increased Activity-Energy, Speech--Rate and Amount, and Disruptive-Aggressive Behavior.
The association of Young Mania Rating Scale item scores with current age was studied in symptomatic inpatients meeting DSM-IV criteria for BP disorder, manic.
The sample consisted of 149 patients ranging in age from 18 to 89 years; 48 of these were male. Age was not associated with differences in overall severity reflected in total score. Age was associated with lower scores on the Sexual Interest item (r = - 0.26, p < 0.001). A trend for higher scores with age on Speech--Rate and Amount (r = 0.19, p < 0.02) did not meet criteria for significance. Increased Activity-Energy, Disruptive-Aggressive Behavior and other item scores were not associated with age. In an exploratory analysis, age and Sexual Interest and Speech item scores were associated in female patients but not in male patients.
These findings suggest that age minimally influences manic psychopathology in patients with BP disorder. The modest correlation between age and Sexual Interest item scores warrants further investigation and the trend for an association between age and Speech--Rate and Amount can be examined in future studies. Possible gender differences in the associations between age and these item scores also invite future study.
临床医生指出,成年期的躁狂精神病理学表现会随着年龄增长而发生变化。我们使用双相(BP)障碍成年患者躁狂精神病理学的评定量表评估,来检验年龄较大是否与与行为过度相关项目的得分有关,即性兴趣、活动-精力增加、言语速率和数量,以及破坏-攻击行为。
在符合DSM-IV标准的BP障碍躁狂症状住院患者中,研究青年躁狂评定量表项目得分与当前年龄之间的关联。
样本包括149名年龄在18至89岁之间的患者;其中48名是男性。年龄与总分所反映的总体严重程度差异无关。年龄与性兴趣项目得分较低相关(r = -0.26,p < 0.001)。言语速率和数量项目得分随年龄增加的趋势(r = 0.19,p < 0.02)未达到显著标准。活动-精力增加、破坏-攻击行为及其他项目得分与年龄无关。在一项探索性分析中,年龄与性兴趣及言语项目得分在女性患者中相关,但在男性患者中不相关。
这些发现表明,年龄对BP障碍患者的躁狂精神病理学影响极小。年龄与性兴趣项目得分之间的适度相关性值得进一步研究,年龄与言语速率和数量之间的关联趋势可在未来研究中进行检验。年龄与这些项目得分之间关联的可能性别差异也有待未来研究。