Lodge Martin A, Bengel Frank M
Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Curr Cardiol Rep. 2007 Apr;9(2):121-8. doi: 10.1007/BF02938338.
Noninvasive quantitative measurement of myocardial perfusion has played an important role in cardiac research and also has potential applications in clinical imaging. Positron emission tomography (PET) methods for measuring absolute perfusion are well established, although the need for an on-site cyclotron has restricted its use to a limited number of centers. Single-photon emission CT (SPECT) also has potential for quantifying myocardial perfusion and has more widespread availability. In this article we review the basic principles of absolute myocardial perfusion quantification and the radiopharmaceuticals that are available for both PET and SPECT. We also examine the extent to which recent developments in instrumentation have increased the practicality of absolute perfusion quantification in PET and the potential for absolute quantification in SPECT.
心肌灌注的无创定量测量在心脏研究中发挥了重要作用，并且在临床成像中也具有潜在应用。用于测量绝对灌注的正电子发射断层扫描（PET）方法已经成熟，尽管需要现场回旋加速器限制了其仅在少数中心使用。单光子发射计算机断层扫描（SPECT）也具有量化心肌灌注的潜力，并且可用性更广泛。在本文中，我们回顾了绝对心肌灌注定量的基本原理以及可用于PET和SPECT的放射性药物。我们还研究了仪器设备的最新进展在多大程度上提高了PET中绝对灌注定量的实用性以及SPECT中绝对定量的潜力。
