Drinkenburg W H, Coenen A M, Vossen J M, Van Luijtelaar E L
Department of Psychology, University of Nijmegen, The Netherlands.
Epilepsy Res. 1991 Sep;9(3):218-24. doi: 10.1016/0920-1211(91)90055-k.
The occurrence of spike-wave discharges was studied in relation to the daily fluctuations of vigilance level in rats. Eight rats of the WAG/Rij strain, an animal model for idiopathic generalized epilepsy of the absence type, which were equipped with cortical EEG and nuchal EMG electrodes, served as subjects. It was found that spike-wave discharges predominantly occur during light slow wave sleep and passive wakefulness. REM sleep, active wakefulness, and deep slow wave sleep are less susceptible to the occurrence of spike-wave discharges. Finally, spike-wave discharges tend to prevail in transitional states. A crucial role for the degree of stability of the level of vigilance in the genesis of absence seizures is suggested.
研究了大鼠中棘波放电的发生与警觉水平每日波动的关系。八只WAG/Rij品系的大鼠作为研究对象，该品系是失神型特发性全身性癫痫的动物模型，它们被植入了皮质脑电图和颈部肌电图电极。研究发现，棘波放电主要发生在轻度慢波睡眠和被动觉醒期间。快速眼动睡眠、主动觉醒和深度慢波睡眠对棘波放电的发生不太敏感。最后，棘波放电倾向于在过渡状态中占主导。这表明警觉水平的稳定程度在失神发作的发生中起关键作用。
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