School of Pharmacy, University of Lincoln, Lincoln LN6 7DL, UK.
Institute of Physiology I, University of Münster, 48149 Münster, Germany.
Cells. 2023 Jun 30;12(13):1761. doi: 10.3390/cells12131761.
Sleep is an essential innate but complex behaviour which is ubiquitous in the animal kingdom. Our knowledge of the distinct neural circuit mechanisms that regulate sleep and wake states in the brain are, however, still limited. It is therefore important to understand how these circuits operate during health and disease. This review will highlight the function of mGlu5 receptors within the thalamocortical circuitry in physiological and pathological sleep states. We will also evaluate the potential of targeting mGlu5 receptors as a therapeutic strategy for sleep disorders that often co-occur with epileptic seizures.
睡眠是一种普遍存在于动物界的基本的、复杂的行为。然而，我们对调节大脑中睡眠和清醒状态的独特神经回路机制的了解仍然有限。因此，了解这些回路在健康和疾病状态下是如何运作的是很重要的。本综述将重点介绍代谢型谷氨酸受体 5（mGlu5）在丘脑皮质回路中的功能，在生理和病理睡眠状态下。我们还将评估靶向 mGlu5 受体作为治疗与癫痫发作常同时发生的睡眠障碍的一种潜在策略。
