Zafar Mona, Jameel Tahir, Abdullah Khalida Nasreen
Department of Gynaecology, Combined Military Hospital, Kharian Cantt.
J Pak Med Assoc. 2007 Mar;57(3):133-6.
To determine the success rate of intrauterine insemination (IUI) in couples presenting with subfertility following controlled ovarian hyperstimulation (COH) by the use of cost effective intrauterine catheter (insertion tube).
An experimental study was conducted at the Obstetric and Gynaecology Departments of Combined Military Hospital Kharian and PNS SHIFA Karachi in collaboration with the Department of Pathology from June 2002 to March 2005. A total of 89 couples were studied, out of which 28 couples presented with abnormal finding in the seminal fluid of husband whereas in 61 couples no identifiable cause could be detected. The mean age of women was 29 years and the duration of infertility was variable. All women had tubal patency confirmed before undergoing COH. IUI was performed at follicular maturity of 18-22 mm. Main outcome measures analyzed were pregnancy rate per cycle of IUI, miscarriage rate and ongoing pregnancy rate. Prognostic factors associated with successful outcome in IUI, such as maternal age and motile sperm count was also observed. For cost effective measures, we used the sterilized disposable insertion tube of the 'Copper-T 380 A' device for insemination of reated sperms into the uterine cavity. Chi-square test was applied to assess the effectiveness of IUI in relation with these variables.
A total of 205 insemination cycles were performed resulting in achievement of pregnancy in 31 patients. Miscarriage occurred in 3 patients. Out of these 31 women who conceived, 21 (67.7%, p=0.003) were aged < 35 years with higher pregnancy rate per cycle (21 / 90 = 23.3%).
Intrauterine insemination may be regarded as valuable procedure for couples presenting at younger age with lesser duration of infertility and unexplained subfertility.
通过使用经济高效的宫内导管（插入管），确定控制性卵巢刺激（COH）后出现生育力低下的夫妇进行宫内人工授精（IUI）的成功率。
2002年6月至2005年3月，在哈里亚联合军事医院妇产科和卡拉奇PNS希法医院与病理科合作开展了一项实验研究。共研究了89对夫妇，其中28对夫妇丈夫精液检查有异常发现，61对夫妇未发现可识别的病因。女性平均年龄为29岁，不孕持续时间各不相同。所有女性在接受COH前均确认输卵管通畅。在卵泡成熟度为18 - 22毫米时进行IUI。分析的主要结局指标为IUI每个周期的妊娠率、流产率和持续妊娠率。还观察了与IUI成功结局相关的预后因素，如产妇年龄和活动精子计数。为采取经济高效的措施，我们使用了“铜T 380 A”装置的无菌一次性插入管将处理后的精子注入子宫腔。应用卡方检验评估IUI与这些变量相关的有效性。
共进行了205个授精周期，31例患者成功妊娠。3例发生流产。在这31例受孕女性中，21例（67.7%，p = 0.003）年龄小于35岁，每个周期的妊娠率较高（21 / 90 = 23.3%）。
对于年龄较轻、不孕持续时间较短且原因不明的不孕夫妇，宫内人工授精可被视为一种有价值的方法。
