Yang J H, Wu M Y, Chao K H, Chen S U, Ho H N, Yang Y S
Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei.
J Reprod Med. 1998 Oct;43(10):903-8.
To examine the combined effects of factors influencing the pregnancy rates following controlled ovarian hyperstimulation (COH) and intrauterine insemination (IUI).
After utilizing the couple as the unit of analysis, 416 couples undergoing COH and IUI with the husband's sperm were studied retrospectively.
The woman's age, postwash total motile sperm counts and number of IUI treatment cycles were three major factors that affected the results of IUI. The predicted cumulative pregnancy rates under different values of the above three factors were therefore calculated using multiple logistic regression analysis and were compared to the pregnancy rate achieved by a cycle of in vitro fertilization and tubal embryo transfer.
Three treatment cycles of IUI are optimal for women aged < or = 34 with postwash total motile sperm counts > 5 x 10(6). For women either aged > or = 35 or with postwash total motile sperm counts < 5 x 10(6), the cumulative pregnancy rates achieved by IUI are extremely low, and other means of assisted reproduction are recommended for couples in those categories. However, this conclusion pertains to our clinics, and other institutions should establish their own data.
探讨影响控制性卵巢刺激（COH）及宫腔内人工授精（IUI）后妊娠率的因素的综合作用。
以夫妇为分析单位，对416例行COH及使用丈夫精子行IUI的夫妇进行回顾性研究。
女性年龄、洗涤后活动精子总数及IUI治疗周期数是影响IUI结果的三个主要因素。因此，采用多元逻辑回归分析计算上述三个因素不同值下的预测累积妊娠率，并与体外受精及输卵管胚胎移植一个周期的妊娠率进行比较。
对于年龄≤34岁且洗涤后活动精子总数>5×10⁶的女性，三个周期的IUI治疗最佳。对于年龄≥35岁或洗涤后活动精子总数<5×10⁶的女性，IUI的累积妊娠率极低，建议此类夫妇采用其他辅助生殖方式。然而，这一结论适用于我们的诊所，其他机构应建立自己的数据。
