[Comparative study on transdermal osmosis in vitro of Aconitum brachypodium liniment, gel and patcher].

OBJECTIVE

To study the transdermal osmosis process of Aconitum brachypodum's liniment, gel and patcher to provide basis for selecting dosage form and controlling the quality.

METHOD

Taking the cumulate rate of transdermal as index, a imitated Fick's diffusion device was used for the investigating the transdermal osmosis course of the three preparations. The best transdermal mathematics models are obtained and the relations between the transdermal course and the release course are analysed.

RESULT

The three preparations have different characteristics of transdermal osmosis course. The liniment meets dynamics 0 order process, the gel and the patcher meet dynamic 0 order process of non-corroded drug system. And the relation is good cubic equation between their transdermal course and release course.

CONCLUSION

The transdermal osmosis experiment in vitro for three preparations can provide basis for selecting dosage form and the quality control in future studies.