Wang Qi-fang, Fan Xiao-wen, Xu Lu, Yao Yu
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhongguo Zhong Yao Za Zhi. 2007 Feb;32(3):218-21.
In the present study, using paeonol as model drug, a new sealed-control temperature method of preparing inclusion complex was developed, the effects of heating temperature, heating time, and crystallinity of beta-cyclodextrin (beta-CD) on formation of inclusion complex and release of the drug were investigated.
A physical mixture of paeonol and beta-CD was sealed in a container, and heated at the desired temperature for the specified time. The inclusion complex of paeonol and beta-CD was confirmed by IR spectrum and powder X-ray diffraction.
The results indicated that the inclusion complex formation of paeonol beta-CD by sealed-control temperature method was affected by heating temperature, heating time, and crystallinity of beta-CD. The inclusion complex was able to inhibit sublimation of paeonol, and dissolution rate of paeonol was increased when the paeonol was included by beta-CD.
Preparation of inclusion complex was simple and quick by sealed-control temperature method.
在本研究中，以丹皮酚为模型药物，开发了一种新的密封控温法制备包合物，研究了加热温度、加热时间和β-环糊精（β-CD）的结晶度对包合物形成及药物释放的影响。
将丹皮酚与β-CD的物理混合物密封于容器中，在所需温度下加热指定时间。通过红外光谱和粉末X射线衍射确认丹皮酚与β-CD的包合物。
结果表明，密封控温法制备丹皮酚-β-CD包合物受加热温度、加热时间和β-CD结晶度的影响。该包合物能够抑制丹皮酚的升华，当丹皮酚被β-CD包合时，其溶解速率增加。
密封控温法制备包合物简单快捷。
