Wu Xue-fen, Zheng Xiao-ke, Yao Hong-jian, Fei Na
Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China.
Zhongguo Zhong Yao Za Zhi. 2005 Apr;30(7):501-3.
Measure the thermal stability and the forming constant of inclusion complex for paeonol with beta-CD, and investigate interaction between beta-CD and paeonol,
The thermal stability investigated by using different thermal analysis. The forming constant was determined by using phase method.
Comparing with melt temperature of paeonol, that of its inclusion complex increase about 220 degrees C. The solubility of paeonol increases with the increased concentration of beta-CD, the composing ratio and the inclusion constant of beta-CD-paeonol is respectively 1/1 and 27.42 mL x mg(-1).
Inclusion constant is applied to research the stability of included drug in physiological condition.
测定丹皮酚与β-环糊精包合物的热稳定性和形成常数，并研究β-环糊精与丹皮酚之间的相互作用。
采用不同的热分析方法研究热稳定性。用相溶解度法测定形成常数。
与丹皮酚的熔点相比，其包合物的熔点提高了约220℃。丹皮酚的溶解度随β-环糊精浓度的增加而增大，β-环糊精-丹皮酚的组成比和包合常数分别为1/1和27.42 mL·mg⁻¹。
包合常数可用于研究生理条件下被包合药物的稳定性。
