Chen Yun-hua, Zhang Shuo-feng, Sun Jian-ning, Wu Jin-ying, Jia Zhan-hong
Beijing City University, Beijing 100094, China.
Zhongguo Zhong Yao Za Zhi. 2007 Feb;32(3):253-6.
To study the effect and the mechanism of Xuesaitong drop pills (total saponins in Radix Notoginseng; XDP) on experimental thrombosis, thrombolysis and blood theology.
First, the rats were randomly divided into five groups: control, XDP (90, 30, 10 mg x kg(-1)), Xuesaitong tablet (XP) 30 mg x kg(-1). Then the effect of the drugs on thrombus and thrombosis was studied after the ratsthrombosis was induced by the arteriovenous shunt. Second, the rats were randomly divided into seven groups: model, XDP (90, 30, 10 mg x kg(-1)), XT (90, 30 mg x kg(-1)), lumbrukinase capsule. Then the effect of the drugs on thrombus and thrombosis was studied after the rats'thrombosis was induced by the electrical stimulation of common carotid artery. Third, the rats were randomly divided into six groups: control, model, XDP (80, 40 mg x kg(-1)), XT (40, 20 mg x kg(-1)). Then the effect of the drugs on blood circulation promoting was observed after the rats'acute blood stasis induced by adrenalin and icy water.
XDP 90, 30 mg x kg(-1) could notably lighten the wet-weight and dry-weight of thrombus in the arteriovenous shunt model in rats in a dose-dependent manner (P < 0.01). XDP 90 mg x kg(-1) with intragastric administration for 3 days had the satisfactory effect on thrombolysis after the rat's thrombosis was induced by the electrical stimulation of common carotid artery (P < 0.01). XDP 80, 40 , 20 mg x kg(-1) reduced significantly erythrocyte aggregation (P < 0.01) and decreased the whole blood viscosity at low shear rate (P < 0.05). XDP 80, 40 mg x kg(-1) reduced the whole blood viscosity at high shear rate and plasma viscosity (P < 0.05). XDP 80 mg x kg(-1) decreased the whole blood viscosity at high shear rate (P < 0.05).
XDP can significantly inhibit the thrombosis and has the satisfactory effect on thrombolysis. One kind of the mechanism is related to the effect on blood rheology.
研究血塞通滴丸（三七总皂苷；XDP）对实验性血栓形成、溶栓及血液流变学的影响及其作用机制。
首先，将大鼠随机分为五组：对照组、XDP（90、30、10mg·kg⁻¹）、血塞通片（XP）30mg·kg⁻¹。采用动静脉旁路法诱导大鼠血栓形成后，观察药物对血栓及血栓形成的影响。其次，将大鼠随机分为七组：模型组、XDP（90、30、10mg·kg⁻¹）、XT（90、30mg·kg⁻¹）、蚓激酶胶囊。采用电刺激大鼠颈总动脉诱导血栓形成后，观察药物对血栓及血栓形成的影响。第三，将大鼠随机分为六组：对照组、模型组、XDP（80、40mg·kg⁻¹）、XT（40、20mg·kg⁻¹）。采用肾上腺素加冰水诱导大鼠急性血瘀后，观察药物对血液循环的影响。
XDP 90、30mg·kg⁻¹能显著减轻大鼠动静脉旁路模型血栓的湿重和干重，且呈剂量依赖性（P<0.01）。XDP 90mg·kg⁻¹灌胃给药3天，对电刺激大鼠颈总动脉诱导的血栓形成有较好的溶栓作用（P<0.01）。XDP 80、40、20mg·kg⁻¹能显著降低红细胞聚集性（P<0.01），降低低切变率下的全血黏度（P<0.05）。XDP 80、40mg·kg⁻¹能降低高切变率下的全血黏度和血浆黏度（P<0.05）。XDP 80mg·kg⁻¹能降低高切变率下的全血黏度（P<0.05）。
血塞通滴丸能显著抑制血栓形成，对溶栓有较好的作用。其作用机制之一与对血液流变学的影响有关。
