Seidelin P H, Struthers A D
Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, UK.
Eur J Clin Pharmacol. 1991;41(2):119-23. doi: 10.1007/BF00265903.
Six normal volunteers were studied on four separate occasions. On each occasion they received two concomitant infusions which were either placebo/placebo, placebo/tyramine, angiotensin II/placebo or angiotensin II/tyramine. Angiotensin II infusion was given at a constant rate of 2ng/kg/min whereas the tyramine infusion consisted of 10 min increments at 1.25, 2.5, 3.75, 5, 7.5 and 10 micrograms.kg-1.min-1. Tyramine infusion caused a dose dependent increase in systolic blood pressure with increases in diastolic blood pressure and plasma noradrenaline only at the highest doses. These changes were not affected by concomitant angiotensin infusion. We have therefore found no evidence to support the enhancement of haemodynamic or plasma noradrenaline responses to tyramine infusion by low dose infusion of angiotensin II in man.
对6名正常志愿者进行了4次单独研究。每次研究时，他们同时接受两种输注，分别是安慰剂/安慰剂、安慰剂/酪胺、血管紧张素II/安慰剂或血管紧张素II/酪胺。血管紧张素II以2ng/kg/分钟的恒定速率输注，而酪胺输注则以1.25、2.5、3.75、5、7.5和10微克·kg-1·min-1的增量进行，每次增量持续10分钟。酪胺输注导致收缩压呈剂量依赖性升高，仅在最高剂量时舒张压和血浆去甲肾上腺素才升高。这些变化不受同时输注血管紧张素的影响。因此，我们没有发现证据支持在人体中低剂量输注血管紧张素II可增强对酪胺输注的血流动力学或血浆去甲肾上腺素反应。
