Monti Giovanna, Bertino Enrico, Muratore Maria Cristina, Coscia Alessandra, Cresi Francesco, Silvestro Leandra, Fabris Claudio, Fortunato Donatella, Giuffrida Maria Gabriella, Conti Amedeo
Department of Paediatric and Adolescence Science, Regina Margherita Children's Hospital, Turin, Italy.
Pediatr Allergy Immunol. 2007 May;18(3):258-64. doi: 10.1111/j.1399-3038.2007.00521.x.
Successful therapy in cow's milk protein allergy rests on completely eliminating cow's milk proteins from the child's diet: it is thus necessary to provide a replacement food. This prospective study investigated tolerance of donkey's milk in a population of 46 selected children with cow's milk protein allergy, for whom it was not possible to use any cow's milk substitute. Thirty-eight children (82.6%) liked and tolerated donkey's milk at the challenge and for the entire duration of follow-up. Catch-up growth was observed in all subjects with growth deficit during cow's milk proteins challenge. The degree of cross-reactivity of immunoglobulin E (IgE) with donkey's milk proteins was very weak and aspecific. Donkey's milk was found to be a valid alternative to both IgE-mediated and non-IgE-mediated cow's milk proteins allergy, including in terms of palatability and weight-height gain.
因此有必要提供替代食物。这项前瞻性研究调查了46名选定的牛奶蛋白过敏儿童对驴奶的耐受性，这些儿童无法使用任何牛奶替代品。38名儿童（82.6%）在激发试验和整个随访期间喜欢并耐受驴奶。在牛奶蛋白激发试验期间所有生长发育迟缓的受试者中均观察到追赶生长。免疫球蛋白E（IgE）与驴奶蛋白的交叉反应程度非常弱且不具有特异性。驴奶被发现是IgE介导和非IgE介导的牛奶蛋白过敏的有效替代品，包括在适口性和体重身高增加方面。
