Chalupa Leo M
Department of Ophthalmology and Vision Science, School of Medicine and Neurobiology, Physiology and Behavior, College of Biological Sciences, University of California, Davis, CA 95616, USA.
Brain Res Rev. 2007 Oct;55(2):228-36. doi: 10.1016/j.brainresrev.2007.03.003. Epub 2007 Mar 13.
In all mammalian species the projections from the two eyes to the dorsal lateral geniculate nucleus of the thalamus terminate in separate layers or territories. This mature projection pattern is refined early in development from an initial state where the inputs of the two eyes are overlapping. Here I discuss the results of studies showing that the formation of segregated eye-specific retinogeniculate projections involves activity-mediated binocular competition. I conclude that while retinal activity undoubtedly is involved in this process, the results of recent studies cast doubt on the prevalent notion that retinal waves of activity play an instructional role in the formation of segregated retinal projections.
在所有哺乳动物物种中，从双眼投射到丘脑背外侧膝状核的纤维终末分布于不同的层或区域。这种成熟的投射模式在发育早期从双眼输入重叠的初始状态开始细化。在此，我讨论一些研究结果，这些结果表明，眼特异性视网膜膝状体投射的分离形成涉及活动介导的双眼竞争。我得出结论，虽然视网膜活动无疑参与了这一过程，但最近的研究结果对视网膜活动波在分离的视网膜投射形成中起指导作用这一普遍观点提出了质疑。
