Lappas C A, Giannakodimos G G
First Obstetrical and Gynecological Department, Elena Venizelou Obstetrical and Gynecological Hospital, Athens, Greece.
Fertil Steril. 1991 Dec;56(6):1196-7. doi: 10.1016/s0015-0282(16)54743-8.
Uncomplicated tubal pregnancies were treated by local injection of methotrexate (25 to 50 mg) and PGF2 alpha (5 to 10 mg). Trophoblastic resorption occurred in 50 (96.1%) of 52 patients within 20 days after treatment and without side effects. Three months after treatment, the affected tube was patent in 43 (91.4%) of 47 patients continuing in the study, and the subsequent intrauterine pregnancy rate was 40.4%. The combined use of methotrexate and PGF2 alpha appears to be a promising treatment for tubal pregnancy and should be evaluated further.
单纯性输卵管妊娠采用局部注射甲氨蝶呤（25至50毫克）和前列腺素F2α（5至10毫克）进行治疗。52例患者中有50例（96.1%）在治疗后20天内发生滋养层吸收，且无副作用。治疗三个月后，继续参与研究的47例患者中有43例（91.4%）患侧输卵管通畅，随后的宫内妊娠率为40.4%。甲氨蝶呤和前列腺素F2α联合使用似乎是一种有前景的输卵管妊娠治疗方法，应进一步评估。
