Vejtorp M, Vejerslev L O, Ruge S
Department of Gynecology and Obstetrics, Huidoure Hospital, Denmark.
Eur J Obstet Gynecol Reprod Biol. 1991 Sep 13;41(2):85-90. doi: 10.1016/0028-2243(91)90084-x.
Thirty women who had a small unruptured tubal pregnancy were treated by laparoscopically guided injection of prostaglandin F2 alpha into the oviduct and into the corpus luteum. They had no side effects. The serum human chorionic gonadotropin (S-HCG) concentration decreased in 25 women to less than 20 IU/l in a median time of 8 days (range 1-45). Five women were operated on because of increasing S-HCG concentration. The median diameter of the oviduct at the site of the gestation, the tubal localisation and the gestational age was similar in the women treated by prostaglandin and those, who were operated on after failure of the procedure. Four of the 6 women, with S-HCG concentrations of more than 2000 IU/l, needed subsequent operative treatment, compared to only one of 24 with a lower concentration. The median duration of the hospital stay after treatment was 2 days for the group of women with a S-HCG concentration of less than 2000 IU/l. Hysterosalpingography 3 months after treatment showed patency on the side of the pregnancy in 12 of 14 women. Prostaglandin injection seems to be an appealing option for the treatment of selected ectopic pregnancies.
30例输卵管妊娠未破裂的女性接受了腹腔镜引导下向输卵管及黄体注射前列腺素F2α的治疗。她们未出现副作用。25名女性的血清人绒毛膜促性腺激素（S-HCG）浓度在中位时间8天（范围1 - 45天）内降至20 IU/l以下。5名女性因S-HCG浓度升高而接受了手术。接受前列腺素治疗的女性与治疗失败后接受手术的女性相比，妊娠部位输卵管的中位直径、输卵管定位及孕周相似。6名S-HCG浓度超过2000 IU/l的女性中有4名需要后续手术治疗，而S-HCG浓度较低的24名女性中只有1名需要后续手术治疗。S-HCG浓度低于2000 IU/l的女性组治疗后的中位住院时间为2天。治疗3个月后的子宫输卵管造影显示，14名女性中有12名妊娠侧输卵管通畅。前列腺素注射似乎是治疗部分异位妊娠的一个有吸引力的选择。
