Li Yin, Jiang Changtao, Wang Xian, Zhang Yan, Shibahara Shigeki, Takahashi Kazuhiro
Department of Physiology and Pathophysiology, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100083, PR China.
Peptides. 2007 May;28(5):1129-43. doi: 10.1016/j.peptides.2007.03.005. Epub 2007 Mar 14.
Adrenomedullin (AM) is a multifunctional regulatory peptide that is produced and secreted by various types of cells. The production and the secretion of AM have been demonstrated in cultured adipocytes and adipose tissues. Inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and lipopolysaccharide are strong stimulators for AM expression in adipocytes. Furthermore, AM expression in the adipose tissue is increased in obesity, and plasma concentrations of AM are increased in obese subjects. One possible (patho)physiological role of AM secreted by adipose tissue may be actions against complications of the metabolic syndrome characterized by obesity, type 2 diabetic mellitus and hypertension, via its antioxidant and potent vasodilator effects. These findings indicate that AM is a new member of the adipokine family.
肾上腺髓质素（AM）是一种多功能调节肽，由多种类型的细胞产生和分泌。在培养的脂肪细胞和脂肪组织中已证实AM的产生和分泌。肿瘤坏死因子-α（TNF-α）和脂多糖等炎性细胞因子是脂肪细胞中AM表达的强刺激物。此外，肥胖时脂肪组织中AM的表达增加，肥胖受试者的血浆AM浓度升高。脂肪组织分泌的AM的一种可能的（病理）生理作用可能是通过其抗氧化和强大的血管舒张作用，对抗以肥胖、2型糖尿病和高血压为特征的代谢综合征的并发症。这些发现表明AM是脂肪因子家族的新成员。
