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Obesity paradox and aging.肥胖悖论与衰老。
Eat Weight Disord. 2021 Feb;26(1):27-35. doi: 10.1007/s40519-019-00815-4. Epub 2019 Dec 21.
2
Assessment of anthropometric indices other than BMI to evaluate arterial stiffness.评估除 BMI 以外的人体测量学指标以评估动脉僵硬度。
Hypertens Res. 2019 Oct;42(10):1599-1605. doi: 10.1038/s41440-019-0264-0. Epub 2019 Apr 24.
3
Midregional proadrenomedullin predicts reduced blood pressure and glucose elevation over time despite enhanced progression of obesity markers.中部分泌型前肾上腺髓质素可预测血压和血糖随时间的降低，尽管肥胖标志物的进展有所增强。
J Hypertens. 2019 Mar;37(3):590-595. doi: 10.1097/HJH.0000000000001893.
4
The epidemiology of obesity.肥胖症的流行病学。
Metabolism. 2019 Mar;92:6-10. doi: 10.1016/j.metabol.2018.09.005. Epub 2018 Sep 22.
5
Body Mass Index and Incident Type 1 and Type 2 Diabetes in Children and Young Adults: A Retrospective Cohort Study.体重指数与儿童及青年1型和2型糖尿病的发病：一项回顾性队列研究。
J Endocr Soc. 2017 Apr 25;1(5):524-537. doi: 10.1210/js.2017-00044. eCollection 2017 May 1.
6
Genetic Variants of RAMP2 and CLR are Associated with Stroke.RAMP2 和 CLR 的遗传变异与中风有关。
J Atheroscler Thromb. 2017 Dec 1;24(12):1267-1281. doi: 10.5551/jat.41517. Epub 2017 Sep 14.
7
Sex differences in fat distribution influence the association between BMI and arterial stiffness.脂肪分布的性别差异影响体重指数与动脉僵硬度之间的关联。
J Hypertens. 2017 Jun;35(6):1219-1225. doi: 10.1097/HJH.0000000000001297.
8
High visceral fat with low subcutaneous fat accumulation as a determinant of atherosclerosis in patients with type 2 diabetes.高内脏脂肪与低皮下脂肪堆积作为2型糖尿病患者动脉粥样硬化的一个决定因素。
Cardiovasc Diabetol. 2015 Oct 7;14:136. doi: 10.1186/s12933-015-0302-4.
9
Cardiac natriuretic peptides in plasma increase after dietary induced weight loss in obesity.肥胖者经饮食诱导体重减轻后，血浆中心钠素水平升高。
BMC Obes. 2014 Dec 2;1:24. doi: 10.1186/s40608-014-0024-2. eCollection 2014.
10
Bench-to-bedside pharmacology of adrenomedullin.肾上腺髓质素的从实验室到临床药理学
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中部分泌型前肾上腺髓质素可以反映内脏脂肪组织的堆积——解释肥胖悖论的关键。

Midregional Proadrenomedullin Can Reflect the Accumulation of Visceral Adipose Tissue-A Key to Explaining the Obesity Paradox.

机构信息

Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.

出版信息

Int J Environ Res Public Health. 2020 Jun 3;17(11):3968. doi: 10.3390/ijerph17113968.

DOI:10.3390/ijerph17113968
PMID:32503285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7312365/
Abstract

BACKGROUND

The aim of this study was to investigate whether plasma midregional proadrenomedullin (MR-proADM) reflected body composition, such as body mass index (BMI), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), VAT/SAT ratio, body fat mass (BFM), and skeletal muscle mass (SMM).

METHODS

A total of 2244 individuals (727 men and 1517 women) were included in the study. Multiple regression analysis was performed to assess the combined influence of variables: age, daily alcohol consumption, Brinkman index, sleeping time, metabolic equivalents, anamnesis for hypertension, dyslipidemia, diabetes, and body composition of MR-proADM, by using a stepwise forward selection method.

RESULTS

MR-proADM was significantly related to all anthropometric indices (BMI, VAT, SAT, VAT/SAT ratio, BFM, and SMM) in men and women. On the basis of a stepwise forward selection method, VAT (men: beta = 0.184, < 0.001, women: beta = 0.203, < 0.001) and BFM (beta = 0.181, < 0.001) in women, were found to be significantly associated with MR-proADM.

CONCLUSION

This study suggests that plasma MR-proADM concentration is a more reliable indicator of VAT for fat distribution, and thus, MR-proADM may help better understand the obesity paradox. Changes in circulating levels of MR-proADM could possibly reflect changes in body composition, endocrine, and metabolic milieu.

摘要

背景

本研究旨在探讨血浆中 midregional proadrenomedullin（MR-proADM）是否反映了身体成分，如体重指数（BMI）、内脏脂肪组织（VAT）、皮下脂肪组织（SAT）、VAT/SAT 比值、体脂肪量（BFM）和骨骼肌量（SMM）。

方法

本研究共纳入 2244 名个体（727 名男性和 1517 名女性）。采用逐步向前选择法进行多元回归分析，评估变量（年龄、每日饮酒量、Brinkman 指数、睡眠时间、代谢当量、高血压病史、血脂异常史、糖尿病史和 MR-proADM 的身体成分）的综合影响。

结果

MR-proADM 与男性和女性所有人体测量指标（BMI、VAT、SAT、VAT/SAT 比值、BFM 和 SMM）均呈显著相关。基于逐步向前选择法，发现 VAT（男性：β=0.184，<0.001；女性：β=0.203，<0.001）和 BFM（女性：β=0.181，<0.001）与 MR-proADM 显著相关。

结论

本研究表明，血浆 MR-proADM 浓度是脂肪分布中 VAT 的更可靠指标，因此，MR-proADM 可能有助于更好地理解肥胖悖论。循环中 MR-proADM 水平的变化可能反映了身体成分、内分泌和代谢环境的变化。