Hill J C, Maske R, Watson P G
Department of Ophthalmology, Groote Schuur Hospital, Cape Town, South Africa.
Eye (Lond). 1991;5 ( Pt 4):420-4. doi: 10.1038/eye.1991.67.
In corneal graft rejection, rapid reversal of the rejection process is necessary to minimise endothelial cell loss. Ten consecutive patients with acute endothelial rejection were treated with a single 500 mg pulse of methylprednisolone intravenously and topical prednisolone 1% drops hourly. The rejection episode was successfully reversed in eight (80%) of the 10 grafts. This preliminary trial indicates that cortico-steroid pulse therapy may be beneficial in the management of severe corneal graft rejection with the advantage of avoiding prolonged oral corticosteroid therapy.
在角膜移植排斥反应中，迅速逆转排斥过程对于将内皮细胞损失降至最低至关重要。连续10例急性内皮排斥反应患者接受了单次静脉注射500毫克甲泼尼龙以及每小时局部滴用1%泼尼松龙滴眼液的治疗。10只移植眼中有8只（80%）的排斥反应发作成功逆转。这项初步试验表明，皮质类固醇脉冲疗法可能有助于治疗严重的角膜移植排斥反应，其优点是避免了长期口服皮质类固醇治疗。
