Nirogi Ramakrishna, Mudigonda Koteshwara, Kandikere Vishwottam
Biopharmaceutical Research, Suven Life Sciences Ltd., Serene Chambers, Road # 7, Banjara Hills, Hyderabad 500034, India.
J Pharm Biomed Anal. 2007 Jun 28;44(2):379-87. doi: 10.1016/j.jpba.2007.02.008. Epub 2007 Feb 13.
The 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors, more commonly known as 'statins', are a novel class of drugs widely used for the treatment of hypercholesterolaemia in patients with established cardiovascular disease as well as those at high risk of developing atherosclerosis. Published chromatographic-mass spectrometric methods for the quantification of presently available seven statins, atorvastatin, simvastatin, lovastatin, pravastatin, fluvastatin, rosuvastatin and pitavastatin are reviewed. High performance liquid chromatography (HPLC) in combination with tandem mass spectrometry (MS/MS) is the analytical technique of choice for the quantification of statins in biological samples. This review envisages that most of the methods used for quantification of statins are in plasma and they are suitable for therapeutic drug monitoring of these drugs.
3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂，更为人熟知的名称是“他汀类药物”，是一类新型药物，广泛用于治疗已患有心血管疾病的高胆固醇血症患者以及有动脉粥样硬化高风险的人群。本文综述了已发表的用于定量分析目前可用的七种他汀类药物（阿托伐他汀、辛伐他汀、洛伐他汀、普伐他汀、氟伐他汀、瑞舒伐他汀和匹伐他汀）的色谱-质谱方法。高效液相色谱（HPLC）与串联质谱（MS/MS）联用是生物样品中他汀类药物定量分析的首选分析技术。本综述认为，大多数用于他汀类药物定量分析的方法是针对血浆的，适用于这些药物的治疗药物监测。
