阿托伐他汀及其中间体的合成与分析的最新进展。

Recent Advances in the Synthesis and Analysis of Atorvastatin and its Intermediates.

机构信息

Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, P.R. China.

Engineering Research Center of Bioconversion and Biopurification of the Ministry of Education, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, P.R. China.

出版信息

Curr Med Chem. 2024;31(37):6063-6083. doi: 10.2174/0109298673263728231004053704.

DOI:10.2174/0109298673263728231004053704

PMID:37828675

Abstract

Atorvastatin, a lipid-lowering drug that is widely used in the treatment of cardiovascular diseases, has significant clinical significance. This article focuses on the synthetic procedures of atorvastatin, including Paal-Knorr synthesis and several new synthetic strategies. It also outlines chemical and chemo-enzymatic methods for synthesizing optically active side chain of atorvastatin. In addition, a comprehensive overview of the analytical monitoring techniques for atorvastatin and its metabolites and impurities is reported, alongside a discussion of their strengths and limitations.

摘要

阿托伐他汀是一种广泛用于治疗心血管疾病的降脂药物，具有重要的临床意义。本文重点介绍了阿托伐他汀的合成步骤，包括 Paal-Knorr 合成和几种新的合成策略。还概述了阿托伐他汀的手性侧链的化学和化学酶法合成方法。此外，还报告了阿托伐他汀及其代谢物和杂质的分析监测技术的综合概述，并讨论了它们的优缺点。