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[复方新诺明治疗耶氏肺孢子菌肺炎失败:巨细胞病毒合并感染的作用?]

[Cotrimoxazole Pneumocystis jiroveci pneumonia treatment failure: co-infection cytomegalovirus role?].

作者信息

Scemama J, Amathieu R, Tual L, Fessenmeyer C, Stirnemann J, Dhonneur G

机构信息

Service d'anesthésie et de réanimation, CHU Jean-Verdier, APHP, Bondy, France.

出版信息

Ann Fr Anesth Reanim. 2007 Jun;26(6):604-7. doi: 10.1016/j.annfar.2007.02.020. Epub 2007 Apr 12.

Abstract

Pneumocystis jiroveci pneumonia is a classic opportunist infection affecting AIDS patients. However it is less frequent since systematic prophylaxis and antiretroviral therapies. Treatment resistance is rare in France. We report the case of a severe Pneumocystis jiroveci pneumonia with treatment resistance to standard treatment and fatal outcome. The different causes of treatment resistance, notably the role of CMV co-infection, were reviewed and discussed.

摘要

耶氏肺孢子菌肺炎是一种影响艾滋病患者的典型机会性感染。然而,自从有了系统的预防措施和抗逆转录病毒疗法后,其发病率有所降低。在法国,治疗耐药情况较为罕见。我们报告了一例严重的耶氏肺孢子菌肺炎病例,该病例对标准治疗产生耐药并导致死亡。我们对治疗耐药的不同原因,尤其是巨细胞病毒合并感染的作用进行了回顾和讨论。

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