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一例肾移植患者并发耶氏肺孢子菌肺炎治疗失败的病例报告。

Therapeutic failure in a renal transplant patient with Pneumocystis jiroveci pneumonia: a case report.

作者信息

Archontoulis Nikolaos K, Staikou Chryssoula V

机构信息

Intensive Care Unit, Laiko General Hospital, Aretaieio Hospital, 11528 Athens, Greece.

出版信息

Exp Clin Transplant. 2009 Jun;7(2):129-32.

Abstract

OBJECTIVES

Pneumocystis jiroveci pneumonia is common in immunocompromised individuals.

PATIENTS

This case report describes an immunosuppressed patient who acquired P jiroveci pneumonia 6 months after renal transplant surgery.

RESULTS

The patient experienced many pneumonia-related complications and adverse effects from drug therapy, and despite treatment with various antibiotic agents, he died on the 62nd day after his admission to the intensive care unit.

CONCLUSIONS

The therapeutic failure of the drug of choice (co-trimoxazole) was evident. This case raises questions about the development of P jiroveci resistance to current therapies.

摘要

目的

耶氏肺孢子菌肺炎在免疫功能低下个体中很常见。

患者

本病例报告描述了一名免疫抑制患者,该患者在肾移植手术后6个月感染了耶氏肺孢子菌肺炎。

结果

该患者出现了许多与肺炎相关的并发症以及药物治疗的不良反应,尽管使用了多种抗生素进行治疗,但他在入住重症监护病房后的第62天死亡。

结论

首选药物(复方新诺明)的治疗失败很明显。该病例引发了关于耶氏肺孢子菌对当前疗法产生耐药性的问题。

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