Reis J P, Tellechea O, Baptista A P
Department of Dermatology, University Hospital, Coimbra, Portugal.
Dermatologica. 1991;183(2):136-8. doi: 10.1159/000247654.
We applied a simple silver staining technique to visualize nucleolar organizer regions associated proteins (AgNORs) for the study of 47 melanocytic lesions (20 malignant melanomas, 5 dysplastic nevi, 4 Spitz nevi, 2 Reed and Gartman's fusiform nevi and 16 melanocytic nevi). A statistically significant difference existed between the numbers of AgNORs per cell in benign and malignant lesions as a group. However, some overlapping counts were found, limiting the usefulness of the technique in differentiating benign from malignant lesions in individual cases.
我们应用一种简单的银染色技术来可视化核仁组织区相关蛋白（AgNORs），以研究47例黑素细胞性病变（20例恶性黑素瘤、5例发育异常痣、4例Spitz痣、2例Reed和Gartman梭形痣以及16例黑素细胞痣）。作为一个整体，良性和恶性病变中每个细胞的AgNORs数量存在统计学上的显著差异。然而，发现了一些重叠的计数，限制了该技术在个别病例中区分良性与恶性病变的实用性。
