Boyman Onur, Purton Jared F, Surh Charles D, Sprent Jonathan
Division of Immunology and Allergy, University Hospital of Lausanne (CHUV), Rue du Bugnon 46, Lausanne, Switzerland.
Curr Opin Immunol. 2007 Jun;19(3):320-6. doi: 10.1016/j.coi.2007.04.015. Epub 2007 Apr 12.
Homeostasis of T cells can be defined as the ability of the immune system to maintain normal T-cell counts and to restore T-cell numbers following T-cell depletion or expansion. These processes are governed by extrinsic signals, most notably cytokines. Two members of the common gamma chain family of cytokines, interleukin (IL)-7 and IL-15, are central to homeostatic proliferation and survival of mature CD4(+) and CD8(+) T cells. Recent evidence suggests that other cytokines, including IL-2, IL-10, IL-12, interferons and TGF-beta, as well as the transcription factors T-bet and eomesodermin all play important but different roles at distinct stages of T-cell homeostasis.
T细胞的稳态可定义为免疫系统维持正常T细胞数量以及在T细胞耗竭或扩增后恢复T细胞数量的能力。这些过程受外在信号调控，其中最显著的是细胞因子。细胞因子共同γ链家族的两个成员，即白细胞介素（IL）-7和IL-15，对于成熟CD4(+)和CD8(+) T细胞的稳态增殖和存活至关重要。最近的证据表明，其他细胞因子，包括IL-2、IL-10、IL-12、干扰素和转化生长因子-β，以及转录因子T-bet和胚外中胚层决定蛋白，在T细胞稳态的不同阶段均发挥重要但不同的作用。
