Reame Nancy E, Lukacs Jane L, Olton Pamela, Ansbacher Rudi, Padmanabhan Vasantha
School of Nursing, University of Michigan, Ann Arbor, Michigan, USA.
Fertil Steril. 2007 Oct;88(4):1003-5. doi: 10.1016/j.fertnstert.2006.12.009. Epub 2007 Apr 16.
To assess the involvement of ovarian-derived regulatory proteins in FSH modulation, we compared FSH, inhibin A, inhibin B, activin A, and follistatin (FS) in 79 women from the following five groups: young cycling, older cycling, perimenopause (PERI), spontaneous menopause (PM), and surgical menopause receiving estrogen (OVX+ET). Although inhibin B varied as expected by ovarian function, no group differences were observed in activin A, barring a tendency for an increase in PERI, while FS 288 was lower in the PERI, PM, and OVX+ET groups and negatively correlated with advancing age.
为评估卵巢源性调节蛋白在促卵泡激素(FSH)调节中的作用,我们比较了来自以下五组的79名女性体内的FSH、抑制素A、抑制素B、激活素A和卵泡抑素(FS):年轻育龄期、年长育龄期、围绝经期(PERI)、自然绝经(PM)以及接受雌激素治疗的手术绝经(OVX+ET)。尽管抑制素B随卵巢功能变化符合预期,但激活素A未观察到组间差异,不过围绝经期有升高趋势,而FS 288在围绝经期、自然绝经组和手术绝经+雌激素组较低且与年龄增长呈负相关。