Becker R, Mende B, Rodloff A C, Wegner R D, Karkut G, Weitzel H K
Klinikum Steglitz, Freie Universität Berlin.
Geburtshilfe Frauenheilkd. 1991 Sep;51(9):704-9. doi: 10.1055/s-2007-1023819.
Between August 1987 and May 1989, bacteriological examinations of smears from the cervical canal was performed in 358 pregnant women, who underwent transcervical sampling of chorionic villi. The outcome of 349 of these pregnancies is documented. 12 of these patients (3.5%) had an artificial abortion for genetic reasons. In 12 other patients, the pregnancy ended before 28 weeks (one child surviving). Microbiological examinations showed that in 187 women (52%), it was possible to culture one or more microorganisms from the cervical canal. The most frequently detected pathogen was Chlamydia trachomatis (111 women, 31%). In pregnancies, where more than one microorganism could be cultured, the risk of following abortion was 8.9 times higher than in those, where no pathogens could be found. In only two of the 12 women with a subsequent spontaneous abortion (16.6%), no microorganism could be found. The bacterial contamination of the cervical canal during TC-CVS seems to be a risk factor for subsequent abortion. Therefore, a bacteriological examination of cervical flora should be performed before as well as during TC-CVS, and antibiotic therapy should be initiated in case of positive results.
1987年8月至1989年5月期间，对358例行经宫颈绒毛取样的孕妇进行了宫颈管涂片细菌学检查。记录了其中349例妊娠的结局。其中12例患者（3.5%）因遗传原因人工流产。另有12例患者妊娠在28周前结束（1名婴儿存活）。微生物学检查显示，187名妇女（52%）的宫颈管中可培养出一种或多种微生物。最常检测到的病原体是沙眼衣原体（111名妇女，31%）。在可培养出多种微生物的妊娠中，随后流产的风险比未发现病原体的妊娠高8.9倍。在随后自然流产的12名妇女中，只有2名（16.6%）未发现微生物。经宫颈绒毛取样时宫颈管的细菌污染似乎是随后流产的一个危险因素。因此，在经宫颈绒毛取样前及取样期间均应进行宫颈菌群的细菌学检查，结果呈阳性时应开始抗生素治疗。
