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Development of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as orally active human chymase inhibitors.

作者信息

Maruoka Hiroshi, Muto Tsuyoshi, Tanaka Taisaku, Imajo Seiichi, Tomimori Yoshiaki, Fukuda Yoshiaki, Nakatsuka Takashi

机构信息

Biomedical Research Laboratories, Daiichi Asubio Pharma Co., Ltd, Mishima-gun, Osaka 618-8513, Japan.

出版信息

Bioorg Med Chem Lett. 2007 Jun 15;17(12):3435-9. doi: 10.1016/j.bmcl.2007.03.085. Epub 2007 Mar 30.

DOI:10.1016/j.bmcl.2007.03.085
PMID:17434735
Abstract

A novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones was designed, synthesized, and evaluated as human chymase inhibitors. From this series, we identified several compounds which were effective, via oral administration, in a mouse model of chronic dermatitis.

摘要

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