用于唾液诊断的微传感器阵列
Microsensor arrays for saliva diagnostics.
作者信息
Walt David R, Blicharz Timothy M, Hayman Ryan B, Rissin David M, Bowden Michaela, Siqueira Walter L, Helmerhorst Eva J, Grand-Pierre Nerline, Oppenheim Frank G, Bhatia Jasvinder S, Little Frédéric F, Brody Jerome S
机构信息
Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, MA 02155, USA.
出版信息
Ann N Y Acad Sci. 2007 Mar;1098(1):389-400. doi: 10.1196/annals.1384.031.
Optical fiber microarrays have been used to screen saliva from patients with end-stage renal disease (ESRD) to ascertain the efficacy of dialysis. We have successfully identified markers in saliva that correlate with kidney disease. Standard assay chemistries for these markers have been converted to disposable test strips such that patients may one day be able to monitor their clinical status at home. Details of these developments are described. In addition, saliva from asthma and chronic obstructive pulmonary disease (COPD) patients is being screened for useful diagnostic markers. Our goal is to develop a multiplexed assay for these protein and nucleic acid biomarkers for diagnosing the cause and severity of pulmonary exacerbations, enabling more effective treatment to be administered. These results are reported in the second part of this article.
光纤微阵列已被用于筛查终末期肾病（ESRD）患者的唾液，以确定透析效果。我们已成功在唾液中鉴定出与肾病相关的标志物。这些标志物的标准检测化学方法已转化为一次性测试条，以便患者有朝一日能够在家中监测自己的临床状况。本文描述了这些进展的详细情况。此外，正在对哮喘和慢性阻塞性肺疾病（COPD）患者的唾液进行筛查，以寻找有用的诊断标志物。我们的目标是开发一种针对这些蛋白质和核酸生物标志物的多重检测方法，用于诊断肺部急性加重的原因和严重程度，从而能够实施更有效的治疗。本文第二部分报告了这些结果。
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