Prescher N, Maier K, Munjal S K, Sorsa T, Bauermeister C-D, Struck F, Netuschil L
Dental Clinic, Friedrich Schiller University, Jena, Germany.
Ann N Y Acad Sci. 2007 Mar;1098:493-5. doi: 10.1196/annals.1384.019.
In a first pilot field study 64 gingival crevicular fluid (GCF) samples were collected from patients of dental practitioners. The dentists (one orthodontist one periodontist, and one general practitioner) were asked to monitor the respective clinical status of the sites of sampling and to collect, if possible, sulcus fluid samples from healthy as well as affected sites from the same patient. The concentration of activated matrix metalloproteinase-8 (aMMP-8) in the GCF was recorded using a set of monoclonal antibodies and a novel DentoAnalyzer. From all three dental offices the distribution of the aMMP-8 values in GCF showed a congruent pattern, where healthy and periodontitis-affected inflamed sites were clearly disparate.
在第一项试点现场研究中，从牙科从业者的患者那里收集了64份龈沟液（GCF）样本。要求牙医（一名正畸医生、一名牙周病医生和一名全科医生）监测采样部位的各自临床状况，并尽可能从同一患者的健康部位和患部收集龈沟液样本。使用一组单克隆抗体和一种新型牙分析仪记录GCF中活化基质金属蛋白酶8（aMMP-8）的浓度。在所有三个牙科诊所中，GCF中aMMP-8值的分布呈现出一致的模式，健康部位和受牙周炎影响的炎症部位明显不同。
