与牙槽骨丧失相关的唾液生物标志物。
Salivary biomarkers associated with alveolar bone loss.
作者信息
Scannapieco F A, Ng Pby, Hovey K, Hausmann E, Hutson A, Wactawski-Wende J
机构信息
Departments of Oral Biology, School of Dental Medicine, State University at Buffalo, Buffalo, NY 14214, USA.
出版信息
Ann N Y Acad Sci. 2007 Mar;1098:496-7. doi: 10.1196/annals.1384.034.
A longitudinal case-control study was performed to measure the association of salivary biomarkers with alveolar bone loss from a sub-sample of 1,256 post-menopausal women enrolled in the Buffalo Women's Health Initiative. From this cohort, 40 subjects with significant alveolar bone loss over a 5-year period were compared to 40 age-matched control subjects having no alveolar bone loss. Several biomarkers were quantitated in saliva collected at baseline by immunoassay. A positive association was noted between alveolar bone loss and salivary concentrations of hepatocyte growth factor, and interleukin-1 beta, while a negative association was noted for alveolar bone loss and salivary osteonectin. This study provides preliminary evidence that several salivary biomarkers measured at baseline may serve to predict future alveolar bone loss.
开展了一项纵向病例对照研究，以测量唾液生物标志物与牙槽骨丧失之间的关联，该研究的子样本来自参与布法罗妇女健康倡议的1256名绝经后女性。从这个队列中，将5年内出现显著牙槽骨丧失的40名受试者与40名年龄匹配、无牙槽骨丧失的对照受试者进行比较。通过免疫测定法对基线时采集的唾液中的几种生物标志物进行定量。研究发现，牙槽骨丧失与唾液中肝细胞生长因子和白细胞介素-1β的浓度呈正相关，而牙槽骨丧失与唾液骨粘连蛋白呈负相关。这项研究提供了初步证据，表明在基线时测量的几种唾液生物标志物可能有助于预测未来的牙槽骨丧失。
Zotero 插件