Felici M G, Spallone V, Maiello M R, Gatta R, Civetta E, Frontoni S, Gambardella S, Menzinger G
Department of Internal Medicine, 2nd University of Rome Tor Vergata, Italy.
Funct Neurol. 1991 Jul-Sep;6(3):299-304.
Previous studies have shown an increased incidence of sudden deaths and lower survival in diabetics with autonomic neuropathy. In hypertensive non diabetic patients a direct correlation has been found between nocturnal blood pressure levels and left ventricular hypertrophy. We have shown in diabetics with autonomic neuropathy a flattening in nocturnal blood pressure reduction and increased 24 hours blood pressure values compared to diabetics without autonomic neuropathy and controls. Our results suggest that abnormalities in 24 hours blood pressure profile might play a role in the increased incidence of cardiovascular morbidity and mortality in diabetics with autonomic neuropathy.
先前的研究表明，自主神经病变的糖尿病患者猝死发生率增加且生存率降低。在高血压非糖尿病患者中，已发现夜间血压水平与左心室肥厚之间存在直接关联。我们发现，与无自主神经病变的糖尿病患者及对照组相比，有自主神经病变的糖尿病患者夜间血压下降变平缓，24小时血压值升高。我们的结果表明，24小时血压模式异常可能在自主神经病变的糖尿病患者心血管发病率和死亡率增加中起作用。
