Lu Fenghe, Sorbara Luigina, Simpson Trefford, Fonn Desmond
Centre for Contact Lens Research, School of Optometry, University of Waterloo, Canada [corrected]
Optom Vis Sci. 2007 Apr;84(4):357-64. doi: 10.1097/OPX.0b013e3180437e55.
To investigate the corneal shape and optical performance following one night of Corneal Refractive Therapy for hyperopia (CRTH).
Twenty subjects (spherical equivalent: -2.14 +/- 2.54 D) were fit with a Paragon CRTH lens (Dk = 100) on one eye randomly. The other eye served as the control. Aberrations, refractive error, and corneal topography at various locations along the horizontal meridian were measured at baseline prior to lens insertion, and immediately after lens removal and at 1, 3, 6, 12, and 28 hours later. Root mean square wavefront errors were measured using a 4.5 mm pupil size.
After one night of CRTH lens wear, the central cornea steepened and paracentral region flattened in the experimental eyes (p < 0.001), whereas no significant location effect was found in the control eyes (p = 0.139). Refractive error (mean +/- SE) changed by 1.23 +/- 0.21 D (p < 0.001). The defocus increased by 0.58 +/- 0.09 microm (p < 0.001). Higher-order aberrations, coma, and spherical aberrations increased by factors of 2.69, 2.58, and 4.07, respectively (all p < 0.001). Spherical aberrations shifted from positive to negative. Astigmatism did not change over time (p = 0.771). All parameters returned to baseline by 28 hours (all p > or = 0.808). Aberrations and refractive error did not change in the control eyes (all p > or = 0.082). CONCLUSIONS.: The CRTH lens steepens the central cornea and flattens the paracentral region, which alters the ametropia by inducing a myopic shift. It appears to be effective for correcting hyperopia and also is reversible.
研究夜间角膜屈光性远视治疗（CRTH）后角膜形态和光学性能。
20名受试者（等效球镜度：-2.14±2.54 D），随机单眼配戴Paragon CRTH镜片（Dk = 100）。另一只眼作为对照。在插入镜片前的基线、取出镜片后即刻以及1、3、6、12和28小时后，测量沿水平子午线不同位置的像差、屈光不正和角膜地形图。使用4.5 mm瞳孔直径测量均方根波前误差。
CRTH镜片配戴一夜后，实验眼中央角膜变陡，旁中央区域变平（p < 0.001），而对照眼中未发现明显的位置效应（p = 0.并139）。屈光不正（平均值±标准误）改变了1.23±0.并21 D（p < 0.001）。散焦增加了0.58±0.并09微米（p < 0.001）。高阶像差、彗差和球差分别增加了2.69、2.58和4.07倍（均p < 0.001）。球差从正值变为负值。散光随时间无变化（p = 0.并771）。所有参数在2并8小时时恢复到基线水平（均p≥0.并808）。对照眼的像差和屈光不正无变化（均p≥0.并082）。结论：CRTH镜片使中央角膜变陡，旁中央区域变平，通过诱导近视性偏移改变屈光不正。它似乎对矫正远视有效且具有可逆性。
