Rosa Moacyr Alexandro, Rosa Marina O, Marcolin Marco A, Fregni Felipe
Clinical Hospital, Institute of Psychiatry, University of Sao Paulo, Brazil.
J ECT. 2007 Mar;23(1):6-8. doi: 10.1097/01.yct.0000263251.68302.f2.
Cardiovascular alterations during electroconvulsive therapy (ECT) are a major concern for this treatment. Although several studies have been performed to compare the effects of anesthetics on these alterations, the results are mixed and doubt still exists regarding the choice of the best drug. We conducted a randomized, double-blind clinical trial to compare the effects of 3 anesthetics used in ECT: etomidate, propofol, and thiopental. Patients (N=30) were randomized to receive one of these drugs as the anesthetic for the ECT procedure. Cardiovascular evaluation consisted of the measurement of blood systolic and diastolic pressure and heart rate before and immediately after the end of the seizure for each patient during a course of ECT. The results showed that etomidate, propofol, and thiopental were associated with similar cardiovascular effects.
电休克治疗（ECT）期间的心血管改变是该治疗的一个主要关注点。尽管已经进行了多项研究来比较麻醉剂对这些改变的影响，但结果不一，对于最佳药物的选择仍存在疑问。我们进行了一项随机、双盲临床试验，以比较ECT中使用的3种麻醉剂的效果：依托咪酯、丙泊酚和硫喷妥钠。患者（N = 30）被随机分配接受这些药物中的一种作为ECT手术的麻醉剂。心血管评估包括在ECT疗程中测量每位患者癫痫发作结束前和结束后立即的收缩压、舒张压和心率。结果表明，依托咪酯、丙泊酚和硫喷妥钠具有相似的心血管效应。
